Rett syndrome (RTT) is a neurodevelopmental disease that results in neurological symptoms involving respiratory dysfunction. Breathing abnormalities are essential criteria for the diagnosis of RTT and include erratic respiratory rhythms and life threatening apneas. These respiratory symptoms are more severe during wakefulness than sleep.
In this case study, VivoSense provided objective, longitudinal respiratory assessment for a multi-center RTT clinical trial. Detailed respiratory waveforms were recorded using the BioRadio’s Respiratory Inductance Plethysmography (RIP) technology and were analyzed to score the frequency of periods of breathing dysregulation over time to objectively determine treatment efficacy.