Articles and Insights About Wearables for Clinical Trials

At the a2 National Symposium: Empowering Innovation in AI/Tech + Aging, Senior Research Scientist Jen Blankenship, PhD, presented our ongoing work with the Center for Human Health and Performance at the University of Massachusetts Amherst to develop digital clinical measures that capture how patients with Alzheimer’s disease function in their real-world environments. 

Here’s an example of how a clinical research team used hypothesis-driven research methods to discover HRV (Heart Rate Variability) associations with stress disorder symptoms in Marines. VivoSense^® software was used to analyze the data collected, ensuring that unusable artifactual data was removed to allow for more accurate findings.

Severe respiratory disease is one of the leading causes of infant illness and death worldwide. There is a significant upward trend of clinical infant respiratory studies, including the investigation into respiratory success in ventilated infants, SIDS, and neurological disorders that affect the normal respiratory pattern. In this article, we discuss how noninvasive respiratory monitoring and VivoSense^® software helps researchers collect and analyze respiratory data for clinical studies focused on infant and neo-natal breathing patterns.

The pace, pressures, work-life balance, and emotional aspects of a physician’s job put them at risk for burnout. A study by the American Medical Association and Mayo Clinic found that burnout rates were particularly increased for specialty practitioners. Drs. Nicholas Slamon and Rob Parker, pediatric ICU physicians at Nemours/Alfred I. duPont Hospital for Children in Wilmington, DE, used VivoSense^® and real-time biometrics of physician stress to study its effects on the care of pediatric patients.

San Diego State University’s Clinical Psychology research group and the Drexel University WELL Center joined forces using VivoSense^® to investigate Heart Rate Variability (HRV) and its link to obesity, binge eating, and loss of control while eating. Specifically, the study examined the association between HRV and binge eating and change in HRV from a resting to a stressed task as a potential marker of emotional regulation capacity in obese individuals.

Here’s an example of how a clinical research team studying stuttering respiratory patterns and other biosignals used VivoSense® software to integrate a multitude of wearable physiological sensor data, manage signal artifacts and produce robust data analysis.

Researchers at the Swiss Federal Institute of Sport Magglingen used VivoSense® Software to study the link between physical activity and its ability to improve resistance to psychosocial stress.

VivoSense continues to lead the way in infant respiratory analysis.

Orange County, CA, February, 2017 – Washington University School of Medicine, and St Louis Children’s Hospital with funding from the NIH Prematurity and Respiratory Outcomes Project (PROP) https://clinicaltrials.gov/ct2/show/NCT01435187 have published early research findings. The primary goal of the PROP study was to identify biomarkers and clinical variables in premature infants that would potentially predict pulmonary status up to one year later.

Roche’s Firefish clinical trial will evaluate drug efficacy against respiratory muscle function and breathing patterns in infants treated for SMA.

Orange County, CA, January, 2017 – Vivonoetics Inc., developer of VivoSense® respiratory testing solutions, announced today that in partnership with Great Lakes NeuroTechnologies, they will be providing advanced respiratory assessment to the Roche FIREFISH study.

In one of the largest studies of active duty combat troops ever conducted Heart Rate Variability (HRV) has been shown to be lowered in post-traumatic stress disorder, PTSD.