Articles and Insights About Wearables for Clinical Trials

Case Studies

Case Study: Sedation

Posted by Dudley Tabakin on January 4, 2013

Respiratory insufficiency in post-operative patients following opioid analgesia is a common and life threatening problem. The efficacy of a candidate drug intended to increase minute ventilation by increasing tidal volume and secondarily through increasing respiratory rate (RR) was investigated in a clinical trial. Respiratory ventilation data were collected over several hours using Respiratory Inductance Plethysmography (RIP) using the Nox-T3 device. VivoSense provided custom routines for integration with sedation drug infusion and calibration against pneumotach data. Subjects were awake for several hours of monitoring, including periods of clinical assessments. VivoSense provided objective artifact management and assessments of key respiratory outcome measures.

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Case Study: PTSD

Posted by Dudley Tabakin on January 3, 2013

UC San Diego researchers investigated whether reduced heart rate variability (HRV) before combat deployment conferred increased risk of a PTSD diagnosis after deployment. HRV from 1500 Marines were measured before combat deployment and again 4-6 months post deployment. The study found that U.S. Marines with reduced HRV prior to deployment displayed increased vulnerability to PTSD upon return, suggesting that a low HRV is a risk factor for developing PTSD.

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Case Study: RETT Syndrome

Posted by Dudley Tabakin on January 2, 2013

Rett syndrome (RTT) is a neurodevelopmental disease that results in neurological symptoms involving respiratory dysfunction. Breathing abnormalities are essential criteria for the diagnosis of RTT and include erratic respiratory rhythms and life threatening apneas. These respiratory symptoms are more severe during wakefulness than sleep.

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Case Study: Type 1 Spinal Muscular Atrophy

Posted by Dudley Tabakin on January 1, 2013

Infants with Spinal Muscular Atrophy (SMA) develop respiratory insufficiency due to progressive respiratory muscle weakness caused by degeneration of alpha motor neurons in the spinal cord. This weakness results in ineffective airway clearance (obstruction), which is the major cause of morbidity and mortality in infants with SMA. Thus, measurement of longitudinal changes in respiratory muscle function in infants and young children with SMA-1 is critical to the evaluation of interventions targeting SMA-1.

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