Science Blog

Wearable Sensors

The Value of Exploratory Endpoints in Early Phase Trials

Posted by Kate Lyden on October 5, 2021

Drug development and clinical care models continue to take a more patient-centered approach. Putting the patient at the center of all phases of medicine is a shift initiated by the FDA. Systematic governance and policy development are currently underway.

A key component to supporting this paradigm shift is the use of real-world evidence collected with wearable sensors. Despite their enormous potential and the pharmaceutical industry’s enthusiasm for their incorporation into drug trials, the majority of digital clinical measures continue to require development – primarily, context-specific clinical validation.

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Measuring Physical Function and Mobility in Real World Settings

Posted by Jen Blankenship on September 16, 2021

Physical function and mobility are relevant to virtually all clinical indications and are significant determinants of an individual’s quality of life. Because of this, function and mobility are often assessed in clinical trials using subjective questionnaires or in clinic performance tests, but these assessments may not reflect a patient’s lived experience. Wearable sensors provide an opportunity to move assessments of function out into the real world to measure how patients feel and function in their own environments.

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Consumer-Grade Activity Trackers Place in Clinical Research

Posted by Patrick Hankey on September 2, 2021

Wearable sensor devices are an essential element for data collection. As their use is rapidly growing, so is the debate whether consumer or medical-grade wearable sensors are fit for purpose in clinical trials.

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Monitoring the Health of First Responders with Wearable Sensors

Posted by Patrick Hankey on July 12, 2021

Recently I had a Q&A session with Alex (Sandy) MacQuarrie, Ph.D., to gain insight into his work with the Hexoskin™ Smart Garment and how it’s used in his research. Hexoskin™ and Astroskin are garment-based platforms that combine ECG, respiratory, pulse oximetry, temperature, and accelerometry sensors.

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How Digital Data Impacts the Development of New Treatments

Posted by Patrick Hankey on June 24, 2021

Digitally connected devices are transforming the way we treat and manage health conditions. They also introduce and improve participant access, engagement, and outcome measurements in clinical trials. Here’s a look at how digital data is paving the way for advances in treatments and recovery.

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Measuring Respiratory-related Outcomes with Wearable Sensors

Posted by Dudley Tabakin on April 8, 2021

Respiratory abnormalities characterize a variety of disorders. In addition to physical disorders, ventilation is profoundly affected by mental and psychophysiological states, including stress, anxiety, and panic disorder. Let’s take a look at the highlights of respiratory-related health issues and the promising wearable technology available to assess respiratory outcome measures in real-world settings.

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Understanding Wearable Sensor Types and Wear Location

Posted by Patrick Hankey on April 1, 2021

When deploying wearable sensors in clinical trials, it is essential to understand how these are positioned on the body. The objective is to maximize the quality of the signal while minimizing burden and maintaining patient comfort. Sensor wear position impacts the accuracy and precision of digital clinical outcome measures.

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An Alternative to the 6MWT in Virtual Clinical Trials

Posted by Patrick Hankey on March 12, 2021

Digital innovation in clinical trial research has been accelerated because of the COVID-19 pandemic. Wherever possible, in-clinical assessments are being replaced with measures taken outside the study site. Decentralized trials present a new challenge to accurately capture data in real-world settings, such as the home or workplace. Here we illustrate how an outcome measure from a wearable sensor can be used as an alternative to the 6-Minute Walk Test (6MWT).

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Digital Health Technologies in Clinical Drug Development

Posted by Dudley Tabakin on February 16, 2021

Digital health technologies have the potential to transform clinical drug development. They can collect continuous, high-resolution data in patients’ real-world environments for extended periods of time, providing researchers with an unprecedented level of insight into patients’ physiological and behavioral states. These types of data may more accurately describe a patient’s experience and enable previously unattainable scientific undertakings.

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Using Wearable Sensors to Assess Sleep-Related Outcome Measures

Posted by Kate Lyden on February 5, 2021

Sleep-related outcome measures obtained with wearable sensors provide valuable data in clinical trials. In addition to reducing the tremendous burden and cost associated with the traditional methods of assessing sleep, they offer an opportunity to take a more in-depth, day-to-day look into how a patient feels, functions, and survives.

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