Respiratory abnormalities characterize a variety of disorders. In addition to physical disorders, ventilation is profoundly affected by mental and psychophysiological states, including stress, anxiety, and panic disorder.
The measurement of respiratory outcomes in the real-world requires careful artifact management. VivoSense ensures high-quality respiratory data are captured via proper protocol design, signal processing, and data analysis procedures.
Thoraco-Abdominal Respiration - Dual-band respiratory inductance plethysmography (RP) sensors are the gold standard for continuous, unobtrusive respiratory monitoring. They are widely used in clinical and research settings, and particularly in polysomnography (sleep studies). Thoracic and abdominal bands allow measurements of both breathing compartments, providing accurate volume and phase relation measurements in addition to simple respiration metrics of rate and timing.
ECG Derived Respiration (EDR) – EDR allows for continuous measurement of respiration rates and timing and has been analytically validated during sleep. Long term monitoring of transient respiratory events is possible while simultaneously enabling ECG measures to be used in a clinical endpoint. E.g., EDR, and HR.
PPG – PPG may be used to determine resting pulse rate and derive continuous measures of respiratory rate. PPG may also be used to assess decompensation via derived SpO2.
Audio – Audio recordings from wearable or app-enabled devices are used to identify cough events. EMG recordings and or patient-reported outcomes (ePRO) of frequency and intensity can enhance cough count.
Sensor Modalities: Audio, RP
Clinical Use Examples: Monitoring biomarker for assessing real-world disease manifestation and severity in a wide range of respiratory indications such as COPD and cystic fibrosis.
Sensor Modalities: ECG, PPG, RP
Clinical Use Examples: Monitoring biomarker to assess recovery time in patients receiving pulmonary rehabilitation.
Monitoring biomarker for identifying exacerbations in patients with COPD.
Sensor Modalities: RP
Clinical Use Examples: Response monitoring biomarker to assess progression severity in obstructive breathing in patients with spinal muscular atrophy (SMA).
Response biomarker to quantify the change in ratio of rib vs. abdomen contribution to breathing in premature infants.
Sensor Modalities: ECG, PPG, RP
Clinical Use Examples: Response biomarker for identifying breath holds in patients receiving treatment for Rett syndrome (RTT).
Response biomarker for patients receiving treatment for sleep apnea.
Sensor Modalities: ECG, PPG, RP
Clinical Use Examples: Monitoring biomarker for aiding in early detection and diagnoses of patients exhibiting symptoms consistent with heart failure.
Sensor Modalities: RP
Clinical Use Examples: Monitoring biomarker to assess disease burden and severity in patients with obstructive sleep apnea.
RP data from a patient with Rett syndrome visualized in VivoSense.
In this example, apneas measured on inspiration (yellow) and expiration (red) comprised the digital endpoint.